:root{--fs-sm: .875rem;--fs-base: 1rem;--fs-md: 1.125rem;--fs-lg: 1.375rem;--fs-xl: 1.75rem;--fs-2xl: 2.25rem;--lh-body: 1.6;--lh-heading: 1.2;--sp-1: .25rem;--sp-2: .5rem;--sp-3: .75rem;--sp-4: 1rem;--sp-5: 1.5rem;--sp-6: 2rem;--sp-7: 3rem;--sp-8: 4rem;--maxw: 72rem;--touch-target: 44px;--z-header: 30;--z-dropdown: 40;--z-overlay: 50}*,*:before,*:after{box-sizing:border-box}*{margin:0}html{-webkit-text-size-adjust:100%}body{font-family:var(--font-body);font-size:var(--fs-base);line-height:var(--lh-body);color:var(--c-text);background:var(--c-bg);min-height:100dvh;display:flex;flex-direction:column}img,svg{display:block;max-width:100%}input,button,select{font:inherit}h1,h2,h3,h4{font-family:var(--font-heading);line-height:var(--lh-heading);color:var(--c-ink);text-wrap:balance}h1{font-size:var(--fs-xl)}h2{font-size:var(--fs-lg)}h3{font-size:var(--fs-md)}p{max-width:70ch}a{color:var(--c-cta)}a:hover{color:var(--c-cta-strong)}:focus-visible{outline:3px solid 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ease}.btn-primary{background:var(--c-cta);color:#fff}.btn-primary:hover{background:var(--c-cta-strong);color:#fff}.btn-secondary{background:var(--c-surface);color:var(--c-ink);border-color:var(--c-border)}.btn-secondary:hover{border-color:var(--c-primary);color:var(--c-primary-strong)}body[data-buttons=pill] .btn{border-radius:999px}.card{background:var(--c-surface);border:1px solid var(--c-border);border-radius:var(--radius-lg);padding:var(--sp-4);box-shadow:var(--shadow-sm)}a.card{display:block;color:inherit;text-decoration:none;transition:border-color .2s ease,box-shadow .2s ease}a.card:hover{border-color:var(--c-primary);box-shadow:var(--shadow-md)}.badge{display:inline-flex;align-items:center;gap:var(--sp-1);padding:.125rem var(--sp-2);border-radius:999px;font-size:var(--fs-sm);font-weight:600}.badge-open{background:var(--c-primary-soft);color:var(--c-primary-strong)}.badge-closed{background:var(--c-danger-soft);color:var(--c-danger)}.badge-info{background:var(--c-cta-soft);color:var(--c-cta-strong)}.sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0 0 0 0);white-space:nowrap;border:0}.muted{color:var(--c-muted)}.text-sm{font-size:var(--fs-sm)}.grid{display:grid;gap:var(--sp-4)}.prose{max-width:46rem}.prose h2{margin-top:var(--sp-6)}.prose h3{margin-top:var(--sp-5)}.prose p,.prose ul,.prose ol{margin-top:var(--sp-3)}.prose li{margin-top:var(--sp-1);margin-left:var(--sp-5)}.prose strong{color:var(--c-ink)}.breadcrumbs ol{display:flex;flex-wrap:wrap;gap:var(--sp-1);list-style:none;padding:0;font-size:var(--fs-sm);color:var(--c-muted)}.breadcrumbs li+li:before{content:"/";margin-inline:var(--sp-1);color:var(--c-border)}.breadcrumbs a{color:var(--c-muted)}.breadcrumbs a:hover{color:var(--c-primary-strong)}.filters{display:flex;flex-wrap:wrap;gap:var(--sp-2);border:0;padding:0}.filter-chip{display:inline-flex;align-items:center;gap:var(--sp-2);min-height:var(--touch-target);padding:var(--sp-1) var(--sp-4);background:var(--c-surface);border:1px solid var(--c-border);border-radius:999px;cursor:pointer;user-select:none;transition:border-color .2s ease,background-color .2s ease}.filter-chip:hover{border-color:var(--c-primary)}.filter-chip:has(input:checked){background:var(--c-primary-soft);border-color:var(--c-primary);color:var(--c-primary-strong);font-weight:600}.filter-chip input{accent-color:var(--c-primary);width:1.1rem;height:1.1rem}@media(min-width:48rem){h1{font-size:var(--fs-2xl)}h2{font-size:var(--fs-xl)}.container{padding-inline:var(--sp-5)}.grid-2{grid-template-columns:repeat(2,1fr)}.grid-3{grid-template-columns:repeat(3,1fr)}}.pharma-cluster{display:flex;align-items:center;justify-content:center;background:var(--c-primary);color:#fff;border-radius:50%;border:2px solid var(--c-surface);font-family:var(--font-heading);font-weight:700;box-shadow:0 0 0 4px var(--c-primary-soft);box-shadow:0 0 0 4px color-mix(in srgb,var(--c-primary) 30%,transparent)}.pharma-cluster span{line-height:1}.pharma-cluster--sm{font-size:.75rem}.pharma-cluster--md{font-size:.85rem}.pharma-cluster--lg{font-size:.95rem}body[data-card=flat] .card{border-color:transparent;box-shadow:none}body[data-card=bordered] .card{box-shadow:none}body[data-card=elevated] .card{border-color:transparent;box-shadow:var(--shadow-md)}body[data-pattern=dots]{background-image:radial-gradient(var(--c-border) 1px,transparent 1px);background-size:22px 22px}body[data-pattern=grid]{background-image:linear-gradient(var(--c-border) 1px,transparent 1px),linear-gradient(90deg,var(--c-border) 1px,transparent 1px);background-size:28px 28px;background-position:-1px -1px}body[data-pattern=waves]{background-image:repeating-linear-gradient(45deg,var(--c-border) 0,var(--c-border) 1px,transparent 1px,transparent 14px)}@media(prefers-reduced-motion:reduce){*,*:before,*:after{animation-duration:.01ms!important;animation-iteration-count:1!important;transition-duration:.01ms!important;scroll-behavior:auto!important}}.site-header[data-astro-cid-ctg3m53h]{position:sticky;top:0;z-index:var(--z-header);background:var(--c-surface);border-bottom:1px solid var(--c-border)}.site-header__inner[data-astro-cid-ctg3m53h]{display:flex;align-items:center;justify-content:space-between;gap:var(--sp-4);min-height:56px}.site-header__brand[data-astro-cid-ctg3m53h]{display:inline-flex;align-items:center;gap:var(--sp-2);font-family:var(--font-heading);font-weight:600;color:var(--c-ink);text-decoration:none}.site-header__nav[data-astro-cid-ctg3m53h]{display:flex;align-items:center;gap:var(--sp-4);list-style:none;padding:0}.site-header__nav[data-astro-cid-ctg3m53h] a[data-astro-cid-ctg3m53h]{display:inline-flex;align-items:center;min-height:var(--touch-target);color:var(--c-text);text-decoration:none;font-weight:500;transition:color .2s ease}.site-header__nav[data-astro-cid-ctg3m53h] a[data-astro-cid-ctg3m53h]:hover{color:var(--c-primary-strong)}body[data-header=centered] .site-header__inner[data-astro-cid-ctg3m53h]{flex-direction:column;gap:0;padding-block:var(--sp-2) 0}body[data-header=centered] .site-header__nav[data-astro-cid-ctg3m53h]{gap:var(--sp-5)}.site-footer[data-astro-cid-gcn2mc3v]{margin-top:var(--sp-7);padding-block:var(--sp-6);background:var(--c-surface);border-top:1px solid var(--c-border);color:var(--c-muted)}.site-footer__links[data-astro-cid-gcn2mc3v]{display:flex;flex-wrap:wrap;gap:var(--sp-2) var(--sp-5);list-style:none;padding:0;margin-bottom:var(--sp-4)}.site-footer__links[data-astro-cid-gcn2mc3v] a[data-astro-cid-gcn2mc3v]{display:inline-flex;align-items:center;min-height:var(--touch-target);color:var(--c-text);text-decoration:none}.site-footer__links[data-astro-cid-gcn2mc3v] a[data-astro-cid-gcn2mc3v]:hover{color:var(--c-primary-strong);text-decoration:underline}.site-footer__note[data-astro-cid-gcn2mc3v]{margin-bottom:var(--sp-3)}.site-footer__network[data-astro-cid-gcn2mc3v]{margin-bottom:var(--sp-4)}.site-footer__network-title[data-astro-cid-gcn2mc3v]{display:block;color:var(--c-muted);margin-bottom:var(--sp-2)}.site-footer__network[data-astro-cid-gcn2mc3v] ul[data-astro-cid-gcn2mc3v]{display:flex;flex-wrap:wrap;gap:var(--sp-2) var(--sp-4);list-style:none;padding:0;margin:0}.site-footer__network[data-astro-cid-gcn2mc3v] a[data-astro-cid-gcn2mc3v]{display:inline-flex;align-items:center;min-height:var(--touch-target);color:var(--c-text)}body[data-footer=columns] .site-footer__links[data-astro-cid-gcn2mc3v]{display:grid;grid-template-columns:repeat(2,minmax(0,max-content));gap:0 var(--sp-7)}@media(min-width:48rem){body[data-footer=columns] .site-footer__links[data-astro-cid-gcn2mc3v]{grid-template-columns:repeat(3,minmax(0,max-content))}}